Based on concepts and data discussed throughout this book, here we introduce the term “Assisted Restoration” (AR) as the sum of approaches required to deliver effective ecological restoration. AR signifies a multidisciplinary strategy with which innovative tools are integrated into routine practices of coral restoration to build sustained resilience for increased survival in a changing world. Coral microbiomes are arguably central targets for active intervention strategies due to their malleability, as well as for monitoring approaches because of their biomarker capacity, serving as indicators of healthy ecosystems. We highlight the role of customized and integrated approaches to optimize coral reef interventions and indicate how artificial intelligence (AI) and standardized data collection methods have the potential to revolutionize the monitoring and analysis of coral reef health under an Assisted Restoration approach. Such an integrative approach is critical to advance ecosystem-scale restoration and is directly connected to planetary and human health under the One Health concept.